An integrative systems genetic analysis of mammalian lipid metabolism.

An integrative systems genetic analysis of mammalian lipid metabolism.

Dysregulation of lipid homeostasis is a precipitating occasion within the pathogenesis and development of hepatosteatosis and metabolic syndrome. These circumstances are extremely prevalent in developed societies and presently have restricted choices for diagnostic and therapeutic intervention. Here, utilizing a proteomic and lipidomic-wide systems genetic strategy, we interrogated lipid regulatory networks in 107 genetically distinct mouse strains to disclose key …

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