Joseph Stevens

An integrative systems genetic analysis of mammalian lipid metabolism.

An integrative systems genetic analysis of mammalian lipid metabolism.

Dysregulation of lipid homeostasis is a precipitating occasion within the pathogenesis and development of hepatosteatosis and metabolic syndrome. These circumstances are extremely prevalent in developed societies and presently have restricted choices for diagnostic and therapeutic intervention. Here, utilizing a proteomic and lipidomic-wide systems genetic strategy, we interrogated lipid regulatory networks in 107 genetically distinct mouse strains to disclose key …

An integrative systems genetic analysis of mammalian lipid metabolism. Read More »

SQSTM1/p62-Directed Metabolic Reprogramming Is Essential for Normal Neurodifferentiation.

SQSTM1/p62-Directed Metabolic Reprogramming Is Essential for Normal Neurodifferentiation.

Neurodegenerative issues are an more and more frequent and irreversible burden on society, typically affecting the growing old inhabitants, however their etiology and illness mechanisms are poorly understood. Studying monogenic neurodegenerative ailments with recognized genetic trigger offers a chance to grasp mobile mechanisms additionally affected in additional complicated issues. We lately reported that loss-of-function mutations within …

SQSTM1/p62-Directed Metabolic Reprogramming Is Essential for Normal Neurodifferentiation. Read More »

Effect of Substrate Topography and Chemistry on Human Mesenchymal Stem Cell Markers: A Transcriptome Study.

Effect of Substrate Topography and Chemistry on Human Mesenchymal Stem Cell Markers: A Transcriptome Study.

The International Society for Cellular Therapy (ISCT) proposed a set of minimal markers for figuring out human mesenchymal stromal cells (hMSCs) in 2007. Since then, with the rising curiosity of higher characterising hMSCs, numerous further floor markers have been proposed. However, the affect of how tradition situations, particularly, the tradition floor, fluctuate the expression of hMSC markers …

Effect of Substrate Topography and Chemistry on Human Mesenchymal Stem Cell Markers: A Transcriptome Study. Read More »