Mesh Fragmentation Improves Dissociation Efficiency in Top-down Proteomics

Mesh Fragmentation Improves Dissociation Efficiency in Top-down Proteomics

Top-down proteomics is a key mass spectrometry-based know-how for complete evaluation of proteoforms. Proteoforms exhibit a number of excessive cost states and isotopic kinds in full MS scans. The dissociation habits of proteoforms in totally different cost states and subjected to totally different collision energies is extremely variable. The present broadly employed data-dependent acquisition (DDA) …

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