Circulating Protein Signatures and Causal Candidates for Type 2 Diabetes.

The increasing prevalence of type 2 diabetes poses a major challenge to societies worldwide. Blood-based factors like serum proteins are in contact with every organ in the body to mediate global homeostasis and may thus directly regulate complex processes such as aging and the development of common chronic diseases. We applied a data-driven proteomics approach, measuring serum levels of 4,137 proteins in 5,438 elderly Icelanders and identified 536 proteins associated with prevalent and/or incident type 2 diabetes. We validated a subset of the observed associations in an independent case-control study of type 2 diabetes.

Mouse Apolipoprotein E (APOE) ELISA Kit

DLR-APOE-Mu-48T 48T
EUR 489
  • Should the Mouse Apolipoprotein E (APOE) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Apolipoprotein E (APOE) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Apolipoprotein E (APOE) ELISA Kit

DLR-APOE-Mu-96T 96T
EUR 635
  • Should the Mouse Apolipoprotein E (APOE) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Apolipoprotein E (APOE) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Porcine Apolipoprotein E (APOE) ELISA Kit

DLR-APOE-p-48T 48T
EUR 547
  • Should the Porcine Apolipoprotein E (APOE) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Apolipoprotein E (APOE) in samples from serum, plasma or other biological fluids.

Porcine Apolipoprotein E (APOE) ELISA Kit

DLR-APOE-p-96T 96T
EUR 715
  • Should the Porcine Apolipoprotein E (APOE) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Apolipoprotein E (APOE) in samples from serum, plasma or other biological fluids.

Rat Apolipoprotein E (APOE) ELISA Kit

DLR-APOE-Ra-48T 48T
EUR 508
  • Should the Rat Apolipoprotein E (APOE) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rat Apolipoprotein E (APOE) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Apolipoprotein E (APOE) ELISA Kit

DLR-APOE-Ra-96T 96T
EUR 661
  • Should the Rat Apolipoprotein E (APOE) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rat Apolipoprotein E (APOE) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rabbit Apolipoprotein E (APOE) ELISA Kit

DLR-APOE-Rb-48T 48T
EUR 508
  • Should the Rabbit Apolipoprotein E (APOE) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A competitive inhibition quantitative ELISA assay kit for detection of Rabbit Apolipoprotein E (APOE) in samples from serum, plasma or other biological fluids.

Rabbit Apolipoprotein E (APOE) ELISA Kit

DLR-APOE-Rb-96T 96T
EUR 661
  • Should the Rabbit Apolipoprotein E (APOE) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A competitive inhibition quantitative ELISA assay kit for detection of Rabbit Apolipoprotein E (APOE) in samples from serum, plasma or other biological fluids.

Human Apolipoprotein E (APOE) ELISA Kit

RDR-APOE-Hu-48Tests 48 Tests
EUR 455

Human Apolipoprotein E (APOE) ELISA Kit

RDR-APOE-Hu-96Tests 96 Tests
EUR 629

Mouse Apolipoprotein E (APOE) ELISA Kit

RDR-APOE-Mu-48Tests 48 Tests
EUR 511

Mouse Apolipoprotein E (APOE) ELISA Kit

RDR-APOE-Mu-96Tests 96 Tests
EUR 709

Porcine Apolipoprotein E (APOE) ELISA Kit

RDR-APOE-p-48Tests 48 Tests
EUR 580

Porcine Apolipoprotein E (APOE) ELISA Kit

RDR-APOE-p-96Tests 96 Tests
EUR 807

Rat Apolipoprotein E (APOE) ELISA Kit

RDR-APOE-Ra-48Tests 48 Tests
EUR 534

Rat Apolipoprotein E (APOE) ELISA Kit

RDR-APOE-Ra-96Tests 96 Tests
EUR 742

Rabbit Apolipoprotein E (APOE) ELISA Kit

RDR-APOE-Rb-48Tests 48 Tests
EUR 534

Rabbit Apolipoprotein E (APOE) ELISA Kit

RDR-APOE-Rb-96Tests 96 Tests
EUR 742

Human Apolipoprotein E (APOE) ELISA Kit

RD-APOE-Hu-48Tests 48 Tests
EUR 436

Human Apolipoprotein E (APOE) ELISA Kit

RD-APOE-Hu-96Tests 96 Tests
EUR 601

Mouse Apolipoprotein E (APOE) ELISA Kit

RD-APOE-Mu-48Tests 48 Tests
EUR 489

Mouse Apolipoprotein E (APOE) ELISA Kit

RD-APOE-Mu-96Tests 96 Tests
EUR 677

Porcine Apolipoprotein E (APOE) ELISA Kit

RD-APOE-p-48Tests 48 Tests
EUR 555

Porcine Apolipoprotein E (APOE) ELISA Kit

RD-APOE-p-96Tests 96 Tests
EUR 771

Rat Apolipoprotein E (APOE) ELISA Kit

RD-APOE-Ra-48Tests 48 Tests
EUR 511

Rat Apolipoprotein E (APOE) ELISA Kit

RD-APOE-Ra-96Tests 96 Tests
EUR 709

Rabbit Apolipoprotein E (APOE) ELISA Kit

RD-APOE-Rb-48Tests 48 Tests
EUR 511

Rabbit Apolipoprotein E (APOE) ELISA Kit

RD-APOE-Rb-96Tests 96 Tests
EUR 709

Custom Antibody titration by ELISA up to 2 rabbits and 1 bleed

ELISA-1 1
EUR 202

APOE

E62B009 20ug
EUR 382

ApoE

MO25042 100 ul
EUR 474

Human APOE ELISA Kit

EHA0526 96Tests
EUR 521

Human APOE ELISA Kit

ELA-E0704h 96 Tests
EUR 824

Goat APOE ELISA Kit

EGTA0526 96Tests
EUR 521

Canine APOE ELISA Kit

ECA0526 96Tests
EUR 521

Chicken APOE ELISA Kit

ECKA0526 96Tests
EUR 521

Anserini APOE ELISA Kit

EAA0526 96Tests
EUR 521

Bovine APOE ELISA Kit

EBA0526 96Tests
EUR 521

APOE ELISA KIT|Human

EF001196 96 Tests
EUR 689

Mouse APOE ELISA Kit

EMA0526 96Tests
EUR 521

Rat APOE ELISA Kit

ERA0526 96Tests
EUR 521

Sheep APOE ELISA Kit

ESA0526 96Tests
EUR 521

Rabbit APOE ELISA Kit

ERTA0526 96Tests
EUR 521

Monkey APOE ELISA Kit

EMKA0526 96Tests
EUR 521

Porcine APOE ELISA Kit

EPA0526 96Tests
EUR 521

Human ApoE ELISA Kit

STA-367 96 assays
EUR 722
Description: The Human ApoE ELISA Kit is an enzyme immunoassay developed for the detection and quantitation of human apolipoprotein in plasma, serum or other biological fluid samples.  Each kit provides sufficient reagents to perform up to 96 assays including standard curve and unknown samples.

Human APOE ELISA Kit

STJ150123 1 kit
EUR 412
Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of ApoE in human serum, plasma and other biological fluids

Mouse APOE ELISA Kit

STJ150264 1 kit
EUR 412
Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of APO-E in Mouse serum, plasma and other biological fluids

ApoE protein

30-1053 50 ug
EUR 1065
Description: Purified native Human ApoE protein

ApoE protein

30-AA30 100 ug
EUR 780
Description: Purified native Human ApoE protein

ApoE antibody

70C-CR9016GAP 100 ug
EUR 137
Description: Affinity purified Goat polyclonal Apo E antibody

ApoE antibody

70C-CR90GAP 100 ug
EUR 241
Description: Purified Polyclonal Goat ApoE antibody

APOE Antibody

35301-100ul 100ul
EUR 252

APOE Antibody

35301-50ul 50ul
EUR 187

ApoE antibody

10R-2370 50 ug
EUR 405
Description: Mouse monoclonal Apolipoprotein E antibody

ApoE antibody

10R-10633 100 ug
EUR 349
Description: Mouse monoclonal ApoE antibody

ApoE antibody

20-S1161G000-V0 10 ml
EUR 203
Description: Goat polyclonal ApoE antibody

ApoE antibody

10R-A136a 50 ug
EUR 418
Description: Mouse monoclonal ApoE antibody

Apoe Antibody

1-CSB-PA001936LA01MO
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against Apoe. Recognizes Apoe from Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB; Recommended dilution: WB:1:1000-1:5000

APOE Antibody

1-CSB-PA07599A0Rb
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against APOE. Recognizes APOE from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF; Recommended dilution: IHC:1:1000-1:2000, IF:1:200-1:500

APOE Antibody

DF4797 200ul
EUR 304
Description: APOE Antibody detects endogenous levels of total APOE.

APOE Antibody

CSB-PA227407-
EUR 335
  • Form: liquid
  • Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific
  • Show more
Description: A polyclonal antibody against APOE. Recognizes APOE from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

APOE Antibody

CSB-PA227407-100ul 100ul
EUR 316
  • Form: liquid
  • Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific
  • Show more
Description: A polyclonal antibody against APOE. Recognizes APOE from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

ApoE antibody

70R-5264 50 ug
EUR 467
Description: Rabbit polyclonal ApoE antibody raised against the N terminal of APOE

ApoE Antibody

BF0404 200ul
EUR 376
Description: ApoE antibody detects endogenous levels of total ApoE.

APOE Antibody

1-CSB-PA009485
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Description: A polyclonal antibody against APOE. Recognizes APOE from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/10000

APOE Antibody

1-CSB-PA009486
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Description: A polyclonal antibody against APOE. Recognizes APOE from Human. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/10000

APOE siRNA

20-abx900378
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol
  • Shipped within 5-10 working days.

APOE siRNA

20-abx907844
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol
  • Shipped within 5-10 working days.

APOE siRNA

20-abx907845
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol
  • Shipped within 5-10 working days.

APOE Antibody

ABD4797 100 ug
EUR 438

APOE antibody

PAab10127 100 ug
EUR 355

ELISA kit for Human APOE

EK5683 96 tests
EUR 519
Description: Enzyme-linked immunosorbent assay kit for quantification of Human APOE in samples from serum, plasma, tissue homogenates and other biological fluids.

Human APOE PicoKine ELISA Kit

EK1455 96 wells
EUR 425
Description: For quantitative detection of human APOE in cell culture supernates, serum, plasma(heparin, EDTA), saliva, milk and urine.

Guinea Pig APOE ELISA Kit

EGA0526 96Tests
EUR 521

ApoE receptor ELISA KIT|Human

EF007481 96 Tests
EUR 689

APOE ELISA Kit (Human) (OKAN04532)

OKAN04532 96 Wells
EUR 792
Description: Description of target: The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 1.8 ng/mL

APOE ELISA Kit (Mouse) (OKAN04694)

OKAN04694 96 Wells
EUR 792
Description: Description of target: This gene encodes a member of the apolipoprotein A1/A4/E family of proteins. This protein is involved in the transport of lipoproteins in the blood. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. Homozygous knockout mice for this gene accumulate high levels of cholesterol in the blood and develop atherosclerosis. Different alleles of this gene have been associated with either increased risk or a protective effect for Alzheimer's disease in human patients. This gene maps to chromosome 7 in a cluster with the related apolipoprotein C1, C2 and C4 genes.;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 6.7 ng/mL

APOE ELISA Kit (Rat) (OKAN05188)

OKAN05188 96 Wells
EUR 792
Description: Description of target: plays a role in plasma lipoprotein transport [RGD, Feb 2006];Species reactivity: Rat;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 2.92 ng/mL

APOE ELISA Kit (Human) (OKBB01004)

OKBB01004 96 Wells
EUR 505
Description: Description of target: Apolipoprotein E (APOE) is a class of apolipoprotein found in the chylomicron and Intermediate-density lipoprotein (IDLs) that is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. In peripheral tissues, APOE is primarily produced by the liver and macrophages, and mediates cholesterol metabolism in an isoform- dependent manner. In the central nervous system, APOE is mainly produced by astrocytes, and transports cholesterol to neurons via APOE receptors, which are members of the low density lipoprotein receptor gene family. This protein is involved in Alzheimer’s disease and cardiovascular disease.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: <50pg/ml

APOE ELISA Kit (Dog) (OKCD06699)

OKCD06699 96 Wells
EUR 1001
Description: Description of target: Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.;Species reactivity: Dog;Application: ELISA;Assay info: ;Sensitivity: < 0.65ng/mL

APOE ELISA Kit (Human) (OKCD06700)

OKCD06700 96 Wells
EUR 596
Description: Description of target: Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 1.9ng/mL

APOE ELISA Kit (Mouse) (OKCD06701)

OKCD06701 96 Wells
EUR 779
Description: Description of target: This gene encodes a member of the apolipoprotein A1/A4/E family of proteins. This protein is involved in the transport of lipoproteins in the blood. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. Homozygous knockout mice for this gene accumulate high levels of cholesterol in the blood and develop atherosclerosis. Different alleles of this gene have been associated with either increased risk or a protective effect for Alzheimer's disease in human patients. This gene maps to chromosome 7 in a cluster with the related apolipoprotein C1, C2 and C4 genes.;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: < 6.7ng/mL

APOE ELISA Kit (Pig) (OKCD06702)

OKCD06702 96 Wells
EUR 1040
Description: Description of target: The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.;Species reactivity: Pig;Application: ELISA;Assay info: ;Sensitivity: < 0.142ng/mL

APOE ELISA Kit (Rat) (OKCD06703)

OKCD06703 96 Wells
EUR 818
Description: Description of target: plays a role in plasma lipoprotein transport.;Species reactivity: Rat;Application: ELISA;Assay info: ;Sensitivity: < 2.92ng/mL

APOE ELISA Kit (Monkey) (OKWB00288)

OKWB00288 96 Wells
EUR 572
Description: Description of target: Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.;Species reactivity: Monkey;Application: ;Assay info: Assay Type: Quantitative Sandwich ELISA;Sensitivity: 3.75 ng/mL

APOE ELISA Kit (Rat) (OKEH03198)

OKEH03198 96 Wells
EUR 662
Description: Description of target: Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.;Species reactivity: Rat;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 3.97 ng/mL

APOE ELISA Kit (Mouse) (OKEH04368)

OKEH04368 96 Wells
EUR 662
Description: Description of target: This gene encodes a member of the apolipoprotein A1/A4/E family of proteins. This protein is involved in the transport of lipoproteins in the blood. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. Homozygous knockout mice for this gene accumulate high levels of cholesterol in the blood and develop atherosclerosis. Different alleles of this gene have been associated with either increased risk or a protective effect for Alzheimer's disease in human patients. This gene maps to chromosome 7 in a cluster with the related apolipoprotein C1, C2 and C4 genes.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 3.96 ng/mL

ApoE Antibody (CT)

6720-100
EUR 316

Apoe Rabbit pAb

A16344-100ul 100 ul
EUR 308

Apoe Rabbit pAb

A16344-200ul 200 ul
EUR 459

Apoe Rabbit pAb

A16344-20ul 20 ul
EUR 183

Apoe Rabbit pAb

A16344-50ul 50 ul
EUR 223

ApoE Rabbit pAb

A12400-100ul 100 ul
EUR 308

ApoE Rabbit pAb

A12400-200ul 200 ul
EUR 459

ApoE Rabbit pAb

A12400-20ul 20 ul
EUR 183

ApoE Rabbit pAb

A12400-50ul 50 ul
EUR 223

ApoE Blocking Peptide

33R-4716 100 ug
EUR 180
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of APOE antibody, catalog no. 70R-5264

These protein associations provide novel biological insights into the molecular mechanisms that are dysregulated prior to and following the onset of type 2 diabetes and can be detected in serum. A bi-directional two-sample Mendelian randomization analysis indicated that serum changes of at least 23 proteins are downstream of the disease or its genetic liability, while 15 proteins were supported as having a causal role in type 2 diabetes.